Quick[ish] talking through my settings.
eatdrink_accordionGet true
Get accordion automatically if you don't have one yet. Stolen if nothing else, Rock and Roll Legend if possible. Saves meat immediately if you're using any type of familiar besides 100% starfish.
eatdrink_accurateMake true
Make sure you have enough ingredients to complete before starting. Disable if you have a VERY slow computer, awesome if it works though.
eatdrink_autosellWhileRonin false
Makes you use much better stuff while in a run. This would happily use cranberry go-goo at a 100k mall value with a 500 meat Value of Adventure, so don't enable this if you're ever going to be selling stuff in the mall. Ever.
eatdrink_avoid_booze-soaked_cherry false
eatdrink_avoid_giant_marshmallow false
eatdrink_avoid_gin-soaked_blotter_paper false
eatdrink_avoid_sponge_cake false
eatdrink_avoid_wet_stew false
Various quest items. If I end up with these in my inventory and they're the best item, I'm happy using them. This isn't the default. You'll need to decide if you'd rather have better food or more adventures spent picking up the wet stew again, etc.
How much is the most a single item should be worth? You can set this to 50000 or higher if you're finding EatDrink is missing items that you'd want, but since I'm mostly ascending at the moment, 10k single item limit protects my rare holiday stuff from errant consumption.
eatdrink_considerCostWhenOwned true
If you set this to false, anything in inventory will be used regardless of value. Generally a bad thing, but amusing if you're planning on quitting and you're wanting to torment the G-D forums.
eatdrink_fav_pr0n_chow_mein true
eatdrink_fav_rockin'_wagon true
eatdrink_fav_twinkly_wad true
eatdrink_favUse false
Left these on defaults, but disabled the favUse, so it ignores them. This is where you'd set white canadians and spaghettis with skullheads for the trophies.
eatdrink_getBartender false
eatdrink_getChef false
If you have these set to true, mafia will try to make helpers for you automatically. I don't generally stay in aftercore long enough for it to matter, but if you're farming for any period of time, set them to true.
How many times/steps should it go through looking for ingredients? More steps extends how long it runs, but also might get you slightly better food. During my testing, 3 got me supercocktails and so forth, which was good enough for me, but if you want it to craft hi-meins, you might need to put it up to 4 or 5.
If this is set to false, it won't make food unless it's the best option, but it won't even consider creating food to be a possibility. That doesn't mean that mafia won't decide it's the best later, but that's on mafia then.
If our mall prices are 2 hours or less, they're accurate enough. Anyways, mafia won't update older prices checked this session unless we buy them, so...
eatdrink_minimumAverage 1.0
If it doesn't give at least 1 adventure, don't consider it. This eliminates stat-only spleen items.
eatdrink_minimumQuality 1
If it doesn't have at least decent (>1 adventure) quality, eliminte the booze/food. This doesn't eliminate spleen, since they don't officially have quality.
We want ode if it's castable.
Why wait 3 seconds repeatedly? I want it to run, now!
eatdrink_piePriority true
If I have a pie and no associated key, eat it first so I get the key.
eatdrink_priceFlexibility 1.25
Go up to 25% above known mall price maximum when retrieving the item.
eatdrink_priceOfNontradeables 999999999
eatdrink_priceOfQuestItems 10
eatdrink_priceOfUnknowns 999999999
If it's a rare or special item, keep it. If it's a quest item I'll be losing on ascension anyways, eat it immediately. Don't set it to 0 or 1, because that means it's skipped (probably), but 10 will make quest items first if it's any good.
eatdrink_simConsume false
eatdrink_simLevel 0
eatdrink_simRonin false
Normally I want to consume, not simulate. But if I'm simulating, use my actual level and ronin status.
Don't spend more than 20k total for food, 20k total for booze, 20k total for spleen, and 20k total for overdrinking per day. This allows them to fill up, but avoids crazy-expensive stuff I really don't care about while mainly ascending, not farming. If you're farming and making good meat, set stepMeat to -1 and it won't cut off your meat spending.
eatdrink_suppressNoMilk true
eatdrink_suppressOverdrink true
If I run EatDrink in run, I know I'm not going to have milk. Don't ask me to confirm it. Same goes for ode... if I don't have enough meat to pay for ode in run, don't ask me to confirm it. Similarly, if I'm asking EatDrink to overdrink, I know I've told it to do that, I don't need another confirmation box.
eatdrink_valueOfNonPrimeStat 2
eatdrink_valueOfPrimeStat 10
Primestat is nice, but not really that important compared to adventures. It's better than regular stats though. If you're trying NOT to level up, set primestat to -1000 or something similar, and EatDrink will try to drop your primestat.
Those are the ones in the vars_<name>.txt file. In mafia's preferences themselves (General->Preferences) you should find:
Buy items from NPC stores whenever needed
If you are out of Ronin, pull items from storage whenever needed
Buy items with tokens at coin masters whenever needed
Buy items from the mall whenever needed
Take items from the closet whenever needed
Set anything you want to true. Only one I have disabled is taking items from the closet, because it leaves me with a way to keep safe items safe.
One more option... this one is in Item Manager->Creatable->Fine Tuning. Value of a turn spent crafting is the visible version of VALUE_OF_ADVENTURE that people talk about often, regarding EatDrink. Figure out how much a turn adventuring is worth to you and set it. This defaults to 500, but if the script is pulling in 2000 meat or more on average, you'll find yourself with significantly more turns if you set this to a more accurate number. I'm currently using 1250 here, because it gives me supercocktails while in-run without a box servant. It all depends on how much meat you'd like to spend and the quality of consumables you'd like to use.
Anyways, that's probably enough of an EatDrink tutorial for now. Yell if you have specific questions about other things and I'll try to clarify.
Edited the post above to hopefully make more sense. Basically, if you're making 2500 meat per adventure, try not to spend that much. Basically, (VOA*adventures)-cost=value of item. It was meant to be a warning against over-estimating your VoA, since you can screw your profits. 
