The last few ascensions I've noticed that the Discard Karma link on the Astral Gash page doesn't work for me. It comes up with the are you sure query, but doesn't discard the karma. Nothing is noted in the GCLi when this occurs. It works fine from inventory. I'd have reported it before, but thought it might have been due to Java 7, but I uninstalled that earlier and still get the issue.