I submitted a bug report to KoL:
This might be intentional, since the powerPixel modifier is pretty severe - but surely small, large, bouncing, etc would still work with it - as well as non-cosmetic modifiers.
I am wearing dice gear, which gives every monster I fight a bunch of OCRS random modifiers.
I equip a Powerful Glove.
I suspect that this is Yet Another Niche Issue, although I ran into it today when I wanted to see how CHEAT CODE: REPLACE MONSTER worked in conjunction with half a dozen pieces of dice gear, regarding my work to re-read random modifiers for transformed monsters. This issue completely derailed that testing.