I expect there will be some changes required for one or more of these things:
Knob Goblin potions (the ones from the dispensary) are some of the things which require Spleen now.December 31 - The abridged dictionary has been removed from Barrrtleby's Barrrgain Books. We'll figure out somewhere harmless to stuff it later.
December 31 - The Talisman o' Nam can no longer be obtained from the pirates. Sorry. It's time.
December 31 - A couple of important quest monsters can no longer be copied. Nerf nerf nerf.
December 31 - Some very old potions have been converted to spleen items. Look forward to more of this kind of thing in the coming weeks.